IDENTIFICATION AND CHARACTERIZATION OF NEW SIGNALS RELEASED BY THE ADIPOSE INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS:

 

• EXTRACELLULAR VESICLES (EVs)  AS BIOMARKERS THAT CORRELATE WITH CLINICAL PARAMETERS DURING THE DEVELOPMENT AND MAINTENANCE OF OBESITY.

 

• EXTRACELLULAR VESICLES (EVs) RELEASED OF ADIPOSE TISSUE (AT) LIKE TROJAN HORSES IN CELLULAR COMMUNICATION AND IN THE DEVELOPMENT OF DISEASES ASSOCIATED WITH OBESITY.

 

• PROTEOMIC ANALYSIS OF SUBCUTANEOUS AND VISCERAL ADIPOSE TISSUE SECRETOMES AND ITS IMPLICATION IN THE DEVELOPMENT AND MAINTENANCE OF OBESITY.

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• DEVELOPMENT AND ADAPTATION OF PROTEOMIC TECHNOLOGIES TO THE STUDY ADIPOSE TISSUE SECRETION (QUANTITATIVE PROTEOMICS: DIGE, SILAC, CILAIR).

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• FUNCTIONAL STUDY OF THE WHITE ADIPOSE TISSUE SECRETOME ACCORDING TO ITS ANATOMICAL LOCATION.

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• ANALYSIS OF SKELETAL MUSCLE SECRETION FOR THE IDENTIFICATION OF REGULATORY SIGNALS OF ENERGY HOMEOSTASIS.

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• STUDY OF THE ROLE OF FNDC5/ IRISIN AS A NEW TARGET MYOKINE/ADIPOKINE FOR THE TREATMENT OF OBESITY AND TYPE 2 DIABETES.

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• CHARACTERIZATION OF FETUIN-A AND MUSCLIN/OSTEOCRIN AS NEW PERIPHERAL SIGNALS INVOLVED IN ENERGY HOMEOSTASIS.

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